Taste Receptor

Taste receptors, part of the G protein-coupled receptor (GPCR) family, mediate sweet, umami, and bitter tastes. They are categorized into two families: TAS1R (T1R1, T1R2, T1R3) and TAS2R (25 human isoforms). TAS1Rs function as heterodimers: TAS1R1/TAS1R3 detects umami (L-amino acids), while TAS1R2/TAS1R3 senses sweet compounds (e.g., sucrose). TAS2Rs bind diverse bitter ligands, initiating signaling through Gα-mediated cAMP reduction and Gβγ-dependent phospholipase C (PLC) activation, leading to calcium release. Taste receptors have also been investigated in several cancers including gastrointestinal, pancreatic, breast, thyroid, acute myeloid leukemia, and head and neck squamous cell carcinoma^[1].

References:

[1]. Carey RM, et al. Impact of sweet, umami, and bitter taste receptor (TAS1R and TAS2R) genomic and expression alterations in solid tumors on survival. Sci Rep. 2022 May 27;12(1):8937. [Content Brief]

Taste Receptor Related Products (17):

By Effects:	Inhibitor (1) Agonists (2) Antagonists (3) Activator (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-100047

Nα,Nα-Bis(carboxymethyl)-L-lysine		98.80%
Nα,Nα-Bis(carboxymethyl)-L-lysine is a competitive inhibitor of bitter taste receptor 4, with an IC₅₀ of 59 nM. Nα,Nα-Bis(carboxymethyl)-L-lysine can be used in bitter receptors related study.

HY-W030796A

Lactisole		99.86%
Lactisole is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit, a glucose-sensing receptor. Lactisole inhibits insulin secretion induced by glucose in mouse islets.

HY-B1146

Denatonium benzoate	Activator	99.90%
Denatonium benzoate (THS-839) is known as the most bitter compound and is commonly used as a deterrent (bittering agent) to activate different types of bitter taste receptors (TAS2Rs) with oral activity. Denatonium benzoate can enhance insulin secretion, has anti-inflammatory effects, and promotes allergy susceptibility .

HY-W011053

Neotame		98.00%
Neotame is a derivative of Aspartame (HY-B0361) and is a flavor enhancer and low-caloric, non-nutritive, high-intensity artificial sweetener that is 7000-13,000 times sweeter than sugar. Neotame causes intestinal epithelial cell death at high concentrations. Neotame induces Apoptosis of Caco-2 cells.

HY-153265

TAS2R14 agonist-2	Inhibitor	99.91%
TAS2R14 agonist-2 (compound 28.1) is a potent and selective TAS2R14 inhibitor with an EC₅₀ value of 72 nM.

HY-108968R

Alitame (hydrate) (Standard)
Alitame (hydrate) (Standard) is the analytical standard of Alitame (hydrate). This product is intended for research and analytical applications. Alitame (hydrate) is a high-intensity sweetener formed from the amino acids L-aspartic acid and D-alanine, and an amine derived from thietane.

HY-W030796R

Lactisole (free acid) (Standard)	Antagonist
Trifluoperazine (dihydrochloride) (Standard) is the analytical standard of Trifluoperazine (dihydrochloride). This product is intended for research and analytical applications. Trifluoperazine dihydrochloride, an antipsychotic agent, acts by blocking central dopamine receptors. Trifluoperazine dihydrochloride is a potent α1-adrenergic receptor antagonist. Trifluoperazine dihydrochloride is a potent NUPR1 inhibitor exerting anticancer activity. Trifluoperazine dihydrochloride is a calmodulin inhibitor, and also inhibits P-glycoprotein. Trifluoperazine dihydrochloride can be used for the research of schizophrenia. Trifluoperazine dihydrochloride acts as a reversible inhibitor of influenza virus morphogenesis.

HY-108968

Alitame hydrate
Alitame (hydrate) is a high-intensity sweetener formed from the amino acids L-aspartic acid and D-alanine, and an amine derived from thietane.

HY-W048510

Epiquinidine	Agonist	98.99%
Epiquinidine, a quinine analogue, can be used as the ggTas2r1 agonist. Epiquinidine activates ggTas2r1 at or beyond 10 µM.

HY-139899

S6821	Antagonist
S6821 is a TAS2R8 antagonist with IC₅₀ value of 0.035 μM. S6821 is not found to be mutagenic or disruptive in vitro, nor is it found to induce micronucleus in bone marrow polychromatic erythrocytes in vivo.

HY-139091

FEMA 4774		99.85%
FEMA 4774 is a positive allosteric modulator of taste receptors T1R2 and T1R3, two subunits of the human sweet taste receptor. FEMA 4774 is also used as a sucrose sweetness enhancer.

HY-153264

TAS2R14 agonist-1	Agonist
TAS2R14 agonist is a potent TAS2R14 partial agonist with an EC₅₀ of 116.6 ±23.6 nM.

HY-W030796AR

Lactisole (Standard)
Bisdemethoxycucurmin (Standard) is the analytical standard of Bisdemethoxycucurmin. This product is intended for research and analytical applications. Bisdemethoxycucurmin (Curcumin III), a curcuminoid, has antioxidant and antiinflammatory activities.

HY-136352

Adenosine 5'-succinate
Adenosine 5'-succinate is a chemically AMP-related compound and potently inhibits Denatonium benzoate/taste receptor activation of transducin.

HY-W030796

Lactisole free acid	Antagonist	99.75%
Lactisole free acid is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit, a glucose-sensing receptor. Lactisole free acid inhibits insulin secretion induced by glucose in mouse islets.

HY-124956

GIV3727
GIV3727 is a bitter taste receptor hTAS2R antagonist, which can inhibit the activation of hTAS2R31 by saccharin and acesulfame potassium, and can effectively reduce the bitter quality of food, beverage and medicine.

HY-W011053A

Neotame (Excipient)
Neotame Excipient can be used as a pharmaceutical excipient, such as a lubricant. Pharmaceutical excipients or pharmaceutical adjuvants refer to other chemical substances used in the pharmaceutical process in addition to the drug ingredients. Pharmaceutical excipients generally refer to inactive ingredients in drug preparations that can improve the stability, solubility and processability of drug preparations. Pharmaceutical excipients can also affect the absorption, distribution, metabolism and elimination (ADME) process of concomitant drugs.

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